Endocrine Abstracts

Diabetic peripheral neuropathy (DPN) is a most common complication of diabetes mellitus. Patients with DPN have chronic, painful symptoms that disrupt sleep, depressed mood and can lead to diminish quality of life. We evaluated clinical characteristics of diabetic peripheral neuropathy in past and present in KoreaWe performed the study to determine the prevalence and to understand the clinical characteristics of diabetic peripheral neuropathy in Koreans ...

Background: The predictive ability of prediabetes defined by HbA1c (5.7–6.4%) or fasting plasma glucose (FPG) criteria (5.6–6.9 mmol/l) for the development of diabetes may differ according to ethnic groups, but only limited longitudinal data are available in Asians. We examined the progression rate to diabetes in Korean adults diagnosed as prediabetes according to these two criteria.Methods: We analyzed data of 9432 Korean adults (age 20–7...

Background and aims: Obesity is an important risk factor for metabolic and cardiovascular disease. Although body mass index (BMI) and waist circumference are convenient and economic methods for assessment of obesity, those could not fully reflect risk for diabetes, hypertension and early atherosclerosis.Materials and methods: We cross-sectionally analyzed anthropometric and laboratory data of 868 Korean adults (age 53.2±11.2 years) which were record...

Kisspeptin (Kp) and its receptor (KISS1R) are essential for reproduction, with dysfunction in their activities leading to reproductive disorders, such as precocious puberty and hypogonadotrophic hypogonadism. Kp is synthesised and secreted within specialist nuclei of the hypothalamus, modulating the HPG axis. Kp is a 54 amino acid peptide, which can undergo proteolytic cleavage into smaller peptides, including Kp10, which retain biological activities. However, little is known ...

The present study was designed to investigate the effects of Diol-ginsenosides, major active components of Panax Ginseng, on the development of diabetes in the Diabetes Prone-BB rats(DP-BB rats). Administration of Diol-ginsenosides to DP-BB rats from age 3-4 weeks to age 11-12 weeks (daily, 1mg/g body weight) resulted in a markedly delayed the onset of diabetes. Islets of the treated rats showed no insulitis or only early/intermediate-stage insulitis and preserved higher pancr...

Introduction: Activating somatic mutation of the BRAF gene (V600E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (32–87%) in various races by different methods.In this study, we report the genetic analysis of BRAF mutation in a Korean cohort of 211 PTC by peptide nucleic acid clamp real-time PCR.Methods: PNA clamp real-time PCR was applied for BRAF analysis ...

Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and is thus the major site of peripheral insulin resistance. Urocortin 2 (Ucn2), a corticotropin releasing factor (CRF) family member and the type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle. To determine the physiological role of Ucn2, we generated mice deficient in this peptide. Using glucose and insulin tolerance tests and hyperinsulinemic euglycemic glucose clamp ...